Stage 3 toxicity is associated with spontaneous abortion, preterm delivery, and maternal death. or =400 mcg/dL are associated with symptomatic iron overdose. The proportions of patients treated with deferoxamine and total dosages of deferoxamine were similar by peak iron level (> or =400 vs. 20mg/mL IV infusion, premixed in water 40mg/mL 80mg/mL injection for dilution 500mg/mL Digitalis Toxicity 1-2 g IVP over 5 minutes, then 1 g/hr drip (if Digibind not available) Monitor levels. 6/56, respectively), or experience maternal death (3/3 vs. 1/56, respectively), deliver preterm (2/3 vs. However, patients with stage 3 toxicity were more likely to spontaneously abort (1/3 vs. Peak iron level > or =400 mcg/dL was not associated with increased risk of spontaneous abortion, preterm delivery, congenital anomalies, or maternal death. Compared with women who had lower peak levels, women with peak serum iron levels > or =400 mcg/dL were more frequently symptomatic (12/13 vs. Fourteen publications were identified, describing 61 cases of obstetric iron overdose, including one recent case at our institution. There were no fatalities among 195,780 exposures to chewable children's vitamins with iron reported by the American Association of Poison Control Centers between 19 6. An estimated ingestion of >60 mg/kg elemental iron, onset of symptoms, blood sugar >150 mg/dL, total leukocyte count >15,000 cumm and presence of iron tablets. This post will help you familiarize yourself with the common antidotes that are used in the hospital setting. Children's chewable vitamins with iron are less likely than adult preparations to cause serious toxicity. The term antidote is a Greek word meaning given against. Acute iron poisoning occurs primarily in children when excessive amounts of iron supplements are ingested, and it may potentially be fatal. Statistical analysis used the Student t-test, Fisher exact test, or ANOVA, as appropriate. An antidote is a substance that can counteract a form of poisoning. Two investigators independently extracted data from articles and their references including stage of toxicity (0 = asymptomatic, 1 = gastrointestinal symptoms, 2 = metabolic disturbance, 3 = organ failure), with differences resolved by consensus. A computer search of the English language literature from 1966-1998 used the key words iron toxicity, iron poisoning, deferoxamine, and pregnancy to identify peer-reviewed papers reporting intentional iron overdoses in pregnancy. The objectives of our study were to 1) determine if peak maternal serum iron level or toxicity stage after intentional overdose is associated with adverse maternal-fetal outcome, and 2) describe the use of deferoxamine antidote therapy in obstetric patients.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |